Topiramate-induced male sexual dysfunction:a report of two cases
10.3760/cma.j.issn.1008-5734.2019.01.019
- VernacularTitle:托吡酯致男性性功能障碍2例
- Author:
Jinyu LIU
1
;
Xiaoqian CHEN
;
Wenjie WANG
;
Chunhua LI
;
Jianqiang NI
;
Qun XUE
;
Min XU
;
Qi FANG
;
Xiaowei HU
Author Information
1. 苏州大学附属第一医院神经内科 215006;苏州大学医学部第一临床学院 215006
- Publication Type:Journal Article
- Keywords:
Topiramate;
Anticonvulsants;
Premature ejaculation;
Erectile dysfunction
- From:
Adverse Drug Reactions Journal
2019;21(1):72-74
- CountryChina
- Language:Chinese
-
Abstract:
Two male patients (patient 1,30 years old;patient 2,54 years old)were treated with topiramate for symptomatic epilepsy and migraine,respectively. The dosage of topiramate in patient 1 was 50 mg/ d and 75 mg/ d in the first and second weeks,respectively,and 100 mg/ d since the third week. Six months after topiramate treatment,the patient told the doctor that his epilepsy did not recur,but he developed hypomnesia,decreased libido,and premature ejaculation when topiramate was taken for 2 weeks. He did not stop topiramate despite that his symptoms persisted. The International Index of Erectile Function (IIEF)score showed that IIEF-1 score was 19 and IIEF-5 score was 16. He was diagnosed as sexual dysfunction. Levetiracetam was given for epilepsy,and topiramate was gradually reduced and finally discontinued within one month. The patient′ s sexual dysfunction improved after 2 weeks of topiramate reduction,disappeared after one month of drug withdrawal,and the IIEF-1 score was 28. The patient 2 took topiramate at a dose of 50 mg/ d. After 2 weeks of topiramate treatment,the patient developed decreased libido and erectile dysfunction. The IIEF-1 score was 23. Because the drug was effective in treating his headache,the patient took topiramate intermittently during headache attacks. The patient′s anaphrodisia and erectile dysfunction persisted.
