Analysis and comparison of bile acid metabolism characteristics in children and adults with metabolic- associated fatty liver disease
10.3760/cma.j.cn501113-20231018-00147
- VernacularTitle:儿童和成人代谢相关脂肪性肝病的胆汁酸代谢特征分析和比较
- Author:
Chuanhao YANG
1
;
Ning MEI
;
Ye WANG
;
Ana LIU
;
Rong RONG
;
Qingtao LYU
;
Minghua ZHENG
;
Yan NI
Author Information
1. 浙江大学医学院附属儿童医院 国家儿童健康与疾病临床医学研究中心，杭州 310005
- Publication Type:Journal Article
- Keywords:
Metabolic-associated fatty liver disease;
Bile acid metabolism;
Mass spectrometry;
Obesity;
Children;
Adults;
Diagnosis
- From:
Chinese Journal of Hepatology
2025;33(7):690-696
- CountryChina
- Language:Chinese
-
Abstract:
Metabolic-associated fatty liver disease has become a common chronic liver disease with changes in lifestyle and the increasing prevalence rate of overweight and obesity in adults and even children. The liver synthesizes bile acids via cholesterol metabolism, which are important signaling molecules that modulate and regulate host glucose, lipid metabolism, and immunity. Abnormal bile acid metabolism closely correlates with the occurrence and progression of metabolic-associated fatty liver disease. This article systematically organizes the research of bile acid metabolism in children and adults with metabolic-associated fatty liver disease from the perspective of analyzing bile acid profiles by mass spectrometry detection, and compares the characteristics of bile acid metabolic disorders across different age groups and different developmental stages of disease so as to provide a reference for subsequent research.
