Neutropenia induced by perindopril and indapamide
10.3760/cma.j.issn.1008-5734.2019.05.020
- VernacularTitle:培哚普利吲达帕胺致中性粒细胞减少
- Author:
Zhipeng YU
1
;
Yulan QIAN
Author Information
1. 苏州大学附属第一医院药学部 215006;苏州明基医院药学部 215011
- Publication Type:Journal Article
- Keywords:
Perindopril;
Indapamide;
Neutropenia;
Drug-related side effects and adverse reactions
- From:
Adverse Drug Reactions Journal
2019;21(5):395-396
- CountryChina
- Language:Chinese
-
Abstract:
A 76-year-old female patient received one perindopril and indapamide tablet (containing perindopril 4.00 mg and indapamide 1.25 mg in each tablet) once daily for hypertension.Her blood pressure was well controlled.One month later,the patient was admitted to hospital for hyperglycemia.On day 2 of admission,the patient developed fever,with the highest body temperature of 38.4 ℃.Laboratory tests showed that her white blood cell count (WBC) was 1.7 × 109/L and neutrophils count was 0.38 × 109/L,which was considered to be related to perindopril and indapamide.Then perindopril and indapamide was discontinued and replaced by amlodipine besylate.And recombinant human granulocyte colony stimulating factor,leucogen,vitamin B4,and anti-infective drugs were also given.On the second day of treatment,the WBC was 6.0 × 109/L and neutrophils count was 4.05 × 109/L.The patient's body temperature returned to normal on day 6 of admission and her WBC,neutrophils count,blood glucose,and blood pressure were 6.2 ×109/L,4.55 × 109/L,6.7 mmol/L,and 128/79 mmHg,respectively on day 8.
