Inherited metabolic liver disease causing copper deposition
10.3760/cma.j.cn501113-20240825-00391
- VernacularTitle:引起肝铜沉积的遗传代谢性肝病
- Author:
Hui JIANG
1
;
Chen LIANG
;
Hui LIU
;
Sujun ZHENG
Author Information
1. 首都医科大学附属北京佑安医院肝病中心一科，北京 100069
- Publication Type:Journal Article
- Keywords:
Inherited metabolic liver disease;
Copper deposition;
Diagnosis;
Differential diagnosis;
Pathological characteristics
- From:
Chinese Journal of Hepatology
2025;33(7):697-703
- CountryChina
- Language:Chinese
-
Abstract:
Copper, as a kind of trace element, is crucial for the physiological functions of various key enzymes in the body, and the liver plays a central role in maintaining copper metabolism. Theoretically, dysfunction in the body’s metabolic processes, such as copper absorption, transportation, and excretion, can lead to copper deposition or deficiency in various organs. Wilson’s disease’s characteristic pathological manifestation is deposition of copper in liver. However, during liver pathological examinations, it has been found in clinical practice that certain patients with non-Wilson's disease and inherited metabolic liver disease may also have copper deposition. This review summarizes the inherited metabolic liver diseases that can cause liver copper deposition, their related pathogenesis, and the differential diagnosis approach from the perspectives of clinical and pathological characteristics.
