Vitamin D intoxication due to overdose of vitamin D2 tablets in a child
10.3760/cma.j.issn.1008-5734.2019.03.013
- VernacularTitle:超剂量服用维生素D2片致幼儿维生素D中毒
- Author:
Zongyan LIU
1
;
Chaoyang CHEN
;
Xianting XIE
;
Guiqing ZHANG
;
Ying ZHOU
;
Yimin CUI
Author Information
1. 北京大学第一医院药剂科 100034;江西省赣州市人民医院药剂科 341000
- Publication Type:Journal Article
- Keywords:
Vitamin D;
Drug overdose;
Poisoning;
Medication errors;
Child
- From:
Adverse Drug Reactions Journal
2019;21(3):225-226
- CountryChina
- Language:Chinese
-
Abstract:
A young girls took irregularly Vitamin D2 tablets (0.25 mg/tablet,each tablet contains 10 000 IU vitamin D2) purchased by her parents at a pharmacy since she was 1.5 years old.The girl took 1 tablet at a time,once to thrice daily,occasionally missing.Five months later,she developed polydipsia and polyuria.She drank more than 2 000 ml water every day,urinated once every 0.5-1 hour,and urinated more than 5 times every night.Her maximum daily urine volume could reach 3 400 ml,and her urine was transparent as clear water.Three weeks after the symptoms appeared,laboratory tests in another hospital showed that blood calcium was 4.34 mmol/L,blood phosphorus was 2.65 mmol/L,and 24-hours urine calcium was 8.0 mmol.Vitamin D poisoning was suspected and her parents were asked to stop feeding the girl vitamin D2 tablets.Rehydration,diuretics and other treatments were given.After 3 days,her blood calcium decreased to 3.60 mmol/L.After 6 days,she was transferred to Peking University First Hospital,where she continued to receive rehydration and symptomatic treatments with a low calcium and phosphorus diet.And after 8 days,the blood calcium was 2.47 mmol/L and 24-hours urine calcium was 2.7 mmol.Her symptoms of polydipsia and polyuria improved and she was discharged.Telephone follow-up 1 month after discharge,the girl's polydipsia and polyuria disappeared and her urine examination was normal.
