Severe liver injury caused by orlistat
10.3760/cma.j.issn.1008-5734.2019.03.016
- VernacularTitle:奥利司他致严重肝损伤
- Author:
Yanlong QIU
1
;
Ling MA
;
Xiaolin ZHU
;
Zhengrong LI
Author Information
1. 平邑县人民医院药剂科,山东省平邑县,273300
- Publication Type:Journal Article
- Keywords:
Liver;
Drug-related side effects and adverse reactions;
Drug-induced liver injury;
Orlistat
- From:
Adverse Drug Reactions Journal
2019;21(3):231-232
- CountryChina
- Language:Chinese
-
Abstract:
A 58-year-old female patient took orlistat 0.12 g orally once daily by herself due to obesity.After 13 months,she developed fatigue and anorexia.Laboratory tests showed alanine aminotransferase(ALT) 1 603 U/L,aspartate aminotransferase(AST) 1 265 U/L,alkaline phosphatase (ALP) 310 U/L,direct bilirubin(DBil) 8.4 μmol/L,and indirect bilirubin(IBil) 13.4 μmol/L.She was diagnosed with liver injury.Orlistat was discontinued,considering its relationship with the liver injury.And an Ⅳ infusion of diammonium glycyrrhizinate 150 mg (added to 250 ml of glucose injection) once daily was given.Two days later,the diammonium glycyrrhizinate was replaced by Ⅳ infusion of magnesium isoglycyrrhizinate 100 mg (added to 100 ml of 0.9％ sodium chloride injection) once daily because that the symptoms did not relieve.After 6 days of treatment with magnesium isoglycyrrhizinate,the patient's symptoms relieved and she had ALT 124 U/L,AST 73 U/L,ALP 73 U/L,DBil 3.1 μmol/L,and IBil 7.3 μmol/L.After 1 month,liver function tests showed ALT 30 U/L,AST 57 U/L,ALP 93 U/L,DBil 3.0 μmol/L,and IBil 11.8 μmol/L.
