The logic of survival in patients with acute liver failure
10.3760/cma.j.cn501113-20250711-00274
- VernacularTitle:急性肝功能衰竭患者的生存逻辑
- Author:
Honglei WENG
1
Author Information
1. 德国海德堡大学曼海姆医学院临床Ⅱ系分子肝病实验室，曼海姆 68167
- Publication Type:Journal Article
- Keywords:
Massive hepatic necrosis;
Acute liver failure;
Liver progenitor cell
- From:
Chinese Journal of Hepatology
2025;33(11):1107-1110
- CountryChina
- Language:Chinese
-
Abstract:
Massive hepatic necrosis (MHN) is defined as hepatocyte death exceeding 70% in the entire liver. Acute liver failure induced by MHN can lead to death in nearly half of patients. However, the vast majority of lost hepatocyte conditions can recover in about half of these patients. Hepatocyte function restoration and gradual differentiation into mature hepatocytes primarily rely on the rapid activation and proliferation of liver progenitor cells (LPCs) in these survived patients. This paper mainly describes the cellular and molecular mechanisms by which LPCs restore liver function and rescue patients following the occurrence of MHN.
