Research progress of tumor-derived exosomes in oral squamous cell carcinoma
10.13591/j.cnki.kqyx.2025.06.013
- VernacularTitle:肿瘤源性外泌体在口腔鳞状细胞癌中的研究进展
- Author:
Xing'an ZHOU
1
;
Bateer DELEHEI
;
Xu WU
;
Hongyu MA
;
Fengjun XIA
;
Tiebing SHEN
;
Duo SHANG
Author Information
1. 内蒙古医科大学附属医院口腔颌面外科,内蒙古呼和浩特(010050)
- Publication Type:Journal Article
- Keywords:
tumor-derived exosomes;
oral squamous cell carcinoma;
interaction;
diagnosis;
treatment;
prognosis
- From:
STOMATOLOGY
2025;45(6):465-469,480
- CountryChina
- Language:Chinese
-
Abstract:
Oral squamous cell carcinoma is a common malignant tumor of the head and neck.Early surgery can achieve good results,but most patients have cervical lymph node metastasis at the time of initial diagnosis.Although surgery combined with radiotherapy or chemotherapy can delay the progression of the disease,the overall prognosis is still not ideal.Especially in patients at stage Ⅲ/Ⅳ,the long-term survival rate has not improved.As a key microbubble in intercellular communication,exosomes contain a large number of biological molecules such as nucleic acids,proteins and lipids.Tumor-derived exosomes play a key role in regulating the tumor micro-environment.This article reviews the effects of tumor-derived exosomes on tumor proliferation,metastasis,immune regulation,diagnosis and treatment in oral squamous cell carcinoma,in order to provide new ideas for early diagnosis and treatment of oral cancer.
