Gouty arthritis induced by pancreatin enteric-coated capsules
10.3760/cma.j.issn.1008-5734.2019.05.021
- VernacularTitle:胰酶肠溶胶囊致痛风性关节炎
- Author:
Hongmei ZHANG
1
;
Jiqiu HOU
;
Lirui SUN
;
Wei ZHOU
Author Information
1. 吉林大学第一医院二部药学部,长春,130031
- Publication Type:Journal Article
- Keywords:
Pancreatin;
Hormone replacement therapy;
Exocrine pancreatic insufficiency;
Arthritis,gouty;
Hyperuricemia
- From:
Adverse Drug Reactions Journal
2019;21(5):397-398
- CountryChina
- Language:Chinese
-
Abstract:
A 30-year-old male patient received pancreatin enteric-coated capsules 0.45 g thrice daily with meals for chronic pancreatitis.On day 9 of medication,the patient developed discomfort in the right first metatarsophalangeal joint.The next day,his symptoms were aggravated,manifested by metatarsophalangeal joint pain and swelling.Laboratory tests showed an increase of uric acid (477 μmol/L),which was considered to be gouty arthritis induced by pancreatin enteric-coated capsules.Then the drug was discontinued and symptomatic treatments such as alkaline urine and analgesics were given.On day 5 of drug withdrawal,the swelling of the right metatarsophalangeal joint was markedly alleviated and the tenderness was significantly relieved.On day 8 of drug withdrawal,swelling and pain in the patient's right metatarsophalangeal joint disappeared and his uric acid level was 430 μmol/L.The patient was discharged.At 2 weeks of follow-up,his uric acid returned to normal.
