Advantages and challenges of auxiliary liver transplantation therapeutic strategies for patients with acute liver failure
10.3760/cma.j.cn501113-20250920-00398
- VernacularTitle:急性肝衰竭患者辅助性肝移植治疗策略的优势与挑战
- Author:
Liying SUN
1
;
Lin WEI
;
Wei QU
;
Zhigui ZENG
;
Haiming ZHANG
;
Zhijun ZHU
Author Information
1. 首都医科大学附属北京友谊医院重症肝病科, 北京 100050
- Publication Type:Journal Article
- Keywords:
Acute liver failure;
Therapeutic;
Auxiliary liver transplantation
- From:
Chinese Journal of Hepatology
2025;33(11):1044-1049
- CountryChina
- Language:Chinese
-
Abstract:
The mortality rates are significantly elevated with the rapid progression of acute liver failure in the absence of timely diagnosis and treatment. Liver transplantation is an effective therapeutic approach that can halt disease progression, but transplantation timing is a crucial factor affecting prognosis. Patients with acute liver failure should be promptly transferred to hospitals equipped for liver transplantation while simultaneously preparing for the procedure during the course of treatment to avoid missing the opportunity to save lives when the condition suddenly worsens. Auxiliary liver transplantation preserves the patient's native liver while transplanting a new liver. Therefore, patients are expected to gradually reduce immunosuppressants following the regeneration of the autologous liver, so avoiding the problem of lifelong use of immunosuppressants. This is also a unique advantage, offering benefits to patients undergoing auxiliary liver transplantation therapy for acute liver failure, while simultaneously presenting challenges for clinicians in terms of technical skill and comprehensive management.
