Clinical efficacy of letrozole combined with Zi Gui Nv Zhen Capsules in patients with PCOS complicated by thin endometrium-induced infertility
10.3969/j.issn.1006-7795.2025.04.008
- VernacularTitle:来曲唑联合资癸女贞胶囊对多囊卵巢综合征子宫内膜薄性不孕患者的疗效观察
- Author:
Jun MA
1
;
Xiangyan RUAN
;
Zhongting XU
;
Yue ZHAO
;
Yuejiao WANG
;
O.Mueck ALFRED
Author Information
1. 首都医科大学附属北京妇产医院/北京妇幼保健院内分泌科,北京 100026
- Publication Type:Journal Article
- Keywords:
Zi Gui Nv Zhen Capsules;
letrozole;
polycystic ovary syndrome(PCOS);
thin endometrium;
infertility;
pregnancy rate
- From:
Journal of Capital Medical University
2025;46(4):632-636
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the curative effect of letrozole combined with Zi Gui Nv Zhen Capsules on patients with polycystic ovary syndrome(PCOS)complicated by thin endometrial infertility.Methods 140 patients with PCOS who met the diagnosis of endometrial thin infertility(endometrial thickness<0.8 cm and no pregnancy for 1 year without contraception)were recruited and randomly assigned to the control group and the experimental group for 3 cycles of treatment.The control group was given letrozole 2.5 mg/d on the 3rd day of menstruation,estradiol valerate 2 mg/d on the 8-10th day of menstruation,and dydrogesterone 10 mg/d in sequence.The experimental group was treated with Zi Gui Nv Zhen Capsules on the basis of the control group.During 3 cycles of treatment,endometrial thickness(EMT),ovulation rate and cumulative pregnancy rate on the day of ovulation were examined.Results The EMT of the experiment group was significantly higher than that of the control group on the ovulation day of three cycles[(0.86±0.23)cm vs(0.71±0.15)cm;(0.83±0.26)cm vs(0.68±0.19)cm;(0.87±0.26)cm vs(0.71±0.11)cm],the cumulative pregnancy rate of experimental group was significantly higher than that of control group(44.3%vs 25.7%).There was no significant difference in ovulation rate between the two groups(P>0.05).Conclusion Our findings demonstrate that the combined use of Zi Gui Nv Zhen Capsule with basic conventional therapy significantly enhances endometrial thickness and improves pregnancy rates in PCOS patients with thin endometrium.
