The role and mechanism of gut microbiota in the development of diabetic nephropathy
10.3969/j.issn.1006-7795.2025.04.024
- VernacularTitle:肠道菌群在糖尿病肾病发生发展中的作用及机制研究进展
- Author:
Mei HAN
1
;
Gang ZHANG
;
Jin ZHAO
;
Anjing WANG
;
Yueqing HUI
;
Shiren SUN
Author Information
1. 西安医学院研究生工作部,西安 710002;第四军医大学西京医院肾脏内科,西安 710032
- Publication Type:Journal Article
- Keywords:
diabetic nephropathy;
gut microbiota;
gut-kidney axis;
metabolites;
probiotics;
fecal microbiota transplantation
- From:
Journal of Capital Medical University
2025;46(4):742-748
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic nephropathy(DN)ranks as a frequent and serious complication in diabetes mellitus,and it's a key factor in chronic kidney disease and end-stage renal disease(ESRD),greatly diminishing the life quality of patients.Presently,the conventional treatment approaches for DN mainly involve strict regulation of blood sugar and pressure,in conjunction with the application of renin-angiotensin-aldosterone system inhibitors.While these therapies can slow down the advancement of DN,they are ineffective in stopping its final development into ESRD.Lately,the involvement of the gut-kidney axis in the development and advancement of DN has attracted growing interest.Individuals suffering from DN show changes in the variety of gut microbiota,which are crucial in the development and management of DN due to metabolic interactions with the host.The goal of this analysis is to explore the fundamental processes of gut microbiota's role in DN and explore treatment approaches focusing on gut microbiota,aiming to offer new perspectives for the clinical handling of DN.
