Research on the role of gastric microbiome in the progression of gastric cancer
10.3969/j.issn.1006-7795.2025.04.015
- VernacularTitle:胃微生物在胃癌进展中的作用
- Author:
Sifan LIU
1
;
Shuyue YANG
1
;
Xu JI
1
;
Zheng ZHANG
1
;
Peng LI
1
Author Information
1. 首都医科大学附属北京友谊医院消化科 消化健康全国重点实验室 国家消化系统疾病临床医学研究中心 胃肠早癌药械研发北京市重点实验室,北京 100050
- Publication Type:Journal Article
- Keywords:
gastric cancer;
tumor;
microbiome;
Helicobacter pylori;
mechanism;
sequencing
- From:
Journal of Capital Medical University
2025;46(4):682-687
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer is a common clinical tumor,and its incidence and mortality rates rank among the top of malignant tumors.Helicobacter pylori(Hp)is an important carcinogenic factor for gastric cancer.Studies have found that in addition to Hp,other microorganisms in the stomach also play a key role in the progression of gastric cancer.The composition and diversity of the gastric microbiota vary significantly under different gastric disease conditions,which may affect the progression of gastric cancer.Hp can induce gastric epithelial inflammation and oxidative stress through various virulence factors,thereby promoting the occurrence of gastric cancer.Non-Hp microorganisms can be involved in the process of gastric cancer through pathways such as metabolic changes and immune regulation.In recent years,with the development of high-throughput sequencing technology,the complexity of gastric microbiota has gradually been revealed,which provides new insights for the early warning and intervention of gastric cancer.This article comprehensively review the role of gastric microbiota in the progression of gastric cancer.
