Effects of Bushen Zhuanggu decoction on t-PINP and β-CTX in patients with knee osteoarthritis
10.3969/j.issn.1673-9701.2025.10.011
- VernacularTitle:补肾壮骨汤对膝骨关节炎患者t-PINP、β-CTX的影响
- Author:
Xuhua SHAO
1
;
Zhiming CHEN
1
;
Jie WEI
1
;
Yifan XU
1
;
Shaohua LI
1
Author Information
1. 杭州市临平区中医院骨伤科,浙江 杭州 311106
- Publication Type:Journal Article
- Keywords:
Knee osteoarthritis;
Bushen Zhuanggu decoction;
Total N-terminal propeptide of type Ⅰ procollagen;
β-C-terminal telopeptide of type Ⅰ collagen
- From:
China Modern Doctor
2025;63(10):47-51
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of Bushen Zhuanggu decoction on total N-terminal propeptide of type Ⅰprocollagen(t-PINP)and β-C-terminal telopeptide of type Ⅰ collagen(β-CTX)in patients with knee osteoarthritis(KOA).Methods A total of 120 patients with liver-kidney deficiency KOA treated in Linping District Hospital of Traditional Chinese Medicine from June 2021 to April 2024 were selected and divided into study group and control group according to random number table method,with 60 cases in each group.The patients of control group was given oral treatment with etocoxib and omeprazole,and patients of study group was given oral treatment of Bushen Zhuanggu decoction on the basis of control group.Both groups were treated for one month.The clinical efficacy,TCM syndrome scores,serum t-PINP and β-CTX leves,t-PINP/β-CTX,Western Ontario and Mcmaster Universities osteoarthritis index(WOMAC)scores and adverse reactions during treatment were compared between two groups.Results The total effective rate in study group was significantly higher than that in control group(x2=4.5 13,P=0.034).After treatment,the TCM syndrome scores,serum t-PINP and β-CTX levels and WOMAC scores in two groups were significantly lower than before treatment,and t-PINP/β-CTX were significantly higher than before treatment(P＜0.05).The TCM syndrome scores,serum t-PINP and β-CTX levels and WOMAC scores in study group were significantly lower than those in control group,and t-PINP/β-CTX was significantly higher than that in control group(P＜0.05).There was no significant difference in incidence of adverse reactions between two groups(x2=0.686,P=0.408).Conclusion Bushen Zhuanggu decoction can improve the clinical efficacy of KOA patients with liver-kidney deficiency,relieve clinical symptoms and pain,increase t-PINP/β-CTX,and reduce the incidence of adverse reactions.
