Analysis of the difference of cerebral vascular morphology and serum indexes between patients with VCIND and cognitively normal cerebral vascular disease
10.3969/j.issn.1673-9701.2025.10.003
- VernacularTitle:VCIND与认知正常脑血管病变患者脑血管形态学及血清指标差异分析
- Author:
Tao ZHANG
1
;
Yunhua ZHENG
;
Ye LIU
;
Tengbo JIANG
;
Xiuling LEI
;
Guizhen JIANG
;
Jingbo XU
Author Information
1. 浙江中医药大学研究生院,浙江 杭州 310053;浙江省医疗健康集团衢州医院(浙江衢化医院)神经内科,浙江衢州 324000
- Publication Type:Journal Article
- Keywords:
Vascular cognitive impairment no dementia;
Cognitive function;
Cerebrovascular morphology
- From:
China Modern Doctor
2025;63(10):11-15
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the differences of cerebral vascular morphology and serum indexes between patients with vascular cognitive impairment no dementia(VCIND)and cognitively normal cerebral vascular disease.Methods A total of 100 VCIND patients hospitalized in Quzhou Hospital of Zhejiang Medical and Health Group from June 2023 to September 2024 were included in experimental group,and 100 cognitively normal patients with cerebral vascular disease hospitalized during the same period were included in control group.Cerebral artery extension and dilation,cerebrovascular stenosis,collateral circulation establishment,inflammatory factors and lipid metabolism indexes were compared between two groups by means of cerebrovascular angiography and serum examination.The relationship between the severity of cognitive impairment and the vascular lesion of different responsibility was also explored.Results The rate of cerebral artery extension and dilation,rate of vascular stenosis in experimental group were higher than those in control group,and the rate of collateral circulation establishment was lower than that in control group(P＜0.05).The levels of interleukin-6,interleukin-1 β,tumor necrosis factor-α,total cholesterol,low density lipoprotein,apolipoprotein B and lipoprotein(a)in experimental group were significantly higher than those in control group,level of high density lipoprotein was lower than that in control group(P＜0.05).In experimental group,there were 20 cases of anterior cerebral artery vascular disease,22 cases of middle cerebral artery vascular disease,26 cases of posterior cerebral artery vascular disease,32 cases of vertebrobasilar artery vascular disease.There were no significant differences in the scores of mini-mental state examination,Montreal cognitive assessment and Hachinski ischemic scale among patients with different responsible vascular diseases(P＞0.05).Conclusion Patients with cerebral artery extension and dilation,cerebral artery stenosis,no establishment of collateral circulation,inflammatory response and abnormal lipid metabolism were high-risk groups for VCIND.Such patients need early cognitive intervention to prevent VCIND occurrence.
