Analyze the mechanism of action of Sini Jia Renshen decoction in the treatment of myocardial infarction complicated with heart failure based on network pharmacology
10.3969/j.issn.1673-9701.2025.10.0010
- VernacularTitle:基于网络药理学分析四逆加人参汤治疗心肌梗死合并心力衰竭的作用机制
- Author:
Xufeng CHEN
1
;
Fuping WU
Author Information
1. 浙江省立同德医院心血管科,浙江 杭州 310012
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Heart failure;
Sini Jia Renshen decoction;
Network pharmacology
- From:
China Modern Doctor
2025;63(10):42-46
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the mechanism of action of Sini Jia Renshen decoction in the treatment of myocardial infarction complicated with heart failure based on network pharmacology.Methods Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform was used to search the active ingredients of Sini Jia Renshen decoction.The target of Sini Jia Renshen decoction was obtained by using String and UniProt database.Targets related to myocardial infarction complicated with heart failure were searched through GeneCards database,OMIM database,etc.Obtain the intersection of the target of the active ingredient and the disease-related target.Gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis of intersection targets were carried out.Results There were 112 active ingredients of Sini Jia Renshen decoction,233 active ingredients and 4980 associated targets of myocardial infarction complicated with heart failure.The intersection targets of drugs and diseases were 188.Quercetin,β-sitosterol,isorhamnetin and naringenin were the core active ingredients of Sini Jia Renshen decoction treatment of myocardial infarction complicated with heart failure.The pathway enrichment analysis showed that it was mainly involved in lipid and atherosclerosis,advanced glycation end product(AGE)/AGE receptor,vascular endothelium activated by shear stress,interleukin-17 and other signaling pathways.Conclusion The treatment of myocardial infarction complicated with heart failure by Sini Jia Renshen decoction has the characteristics of multi-components,multi-targets and multi-pathways.It may play a role in myocardial infarction complicated with heart failure through lipid and atherosclerosis pathways and so on.
