Improvement of cognitive function in elderly stroke patients by virtual reality combined with computerized cognitive training intervention
10.3969/j.issn.1009-0126.2025.04.008
- VernacularTitle:虚拟现实技术联合计算机化认知训练干预对老年脑卒中患者认知功能的改善研究
- Author:
Shanhu ZHOU
1
;
Xin ZHANG
;
Huiqing LIU
;
Wei CHENG
;
Zhongjin ZHANG
Author Information
1. 430081 武汉市普仁医院神经内科
- Publication Type:Journal Article
- Keywords:
virtual reality;
stroke;
cognition;
exercise therapy
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(4):431-435
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore whether virtual reality(VR)combined with computerized cogni-tive training intervention can improve the cognitive function in elderly stroke patients.Methods A total of 202 stroke patients admitted to our department from January 2022 to January 2024 were recruited and randomly divided into control group(101 cases,traditional cognitive training intervention)and study group(101 cases,VR combined with computerized cognitive training in-tervention).Before and after 3 months of intervention,Montreal Cognitive Assessment Scale(MoCA),Mini-Mental State Examination(MMSE),National Institutes of Health Stroke Scale(NIHSS),Fugl-Meyer Assessment(FMA),Activities of Daily Living Scale(ADL)were applied,serum levels of dopamine,neuropeptide Y(NPY),5-hydroxytryptamine(5-HT)and norepineph-rine(NE)were detected,and P300 wave of event-related potential was measured.The results were compared before and after intervention,and between the two groups.Results After intervention,the scores of MoCA,MMSE and FMA,the levels of NPY,5-HT,NE,dopamine,and the ampli-tude of P300 wave were obviously higher in both groups when compared with those before inter-vention(P＜0.05).The study group obtained notably higher MoCA score(27.64±0.62 vs 26.83±0.65),MMSE score(27.67±0.61 vs 26.83±0.62),NPY,5-HT,NE,dopamine,FMA score and amplitude of P300 wave after intervention than the control group(P＜0.01).The NIHSS score,ADL score and latency in the two groups after intervention were significantly lower than those before intervention(P＜0.05),and the above indicators in the study group were significantly low-er than the control group(P＜0.01).Conclusion VR combined with computerized cognitive training intervention can effectively improve the cognitive function,neurological function,motor function and daily life function,and enhance the neurotransmitter levels in elderly stroke patients.
