Analysis of immune checkpoints,prognostic related molecules,and po-tential sensitive drugs in colorectal cancer based on TCGA database and bioinformatics methods
10.3969/j.issn.1009-9905.2025.06.004
- VernacularTitle:基于TCGA数据库与生物信息学方法分析结直肠癌的免疫检查点、预后相关分子和潜在敏感药物
- Author:
Yue WU
1
;
Yi-jun ZHANG
;
Yin-zhong WANG
;
Yan-yan ZHANG
Author Information
1. 焦作市第二人民医院(河南理工大学第一附属医院)普通外科(河南 焦作 454000)
- Publication Type:Journal Article
- Keywords:
Colorectal cancer;
Immune checkpoint;
Prognosis;
Drug susceptibility;
Tissue inhibitor of metallopro-teinase 1
- From:
Chinese Journal of Current Advances in General Surgery
2025;28(6):444-450
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate biomarkers that are significantly associated with the immune checkpoint(ICs)genes of colorectal cancer(CRC)and have a key impact on the prognosis of patients,and to search for related sensitive drugs by using bioinformatics methods.Methods:Genes with up-regulated expression in TCGA database and associated with poor prognosis of patients were screened,and molecules with high correlation with immune checkpoint were extracted to verify their impact on the prognosis of patients with colorectal cancer.Finally,their im-pact on immune cell infiltration and correlation were detected,and sensitive drugs that act on target genes were ana-lyzed and searched.Results:Colorectal cancer patients with up-regulated expression of tissue inhibitor of metallo-proteinase 1(TIMP1)had poor prognosis.Different TIMP1 expression levels showed significant differences in the infil-tration levels of various immune cells.Further drug sensitivity analysis predicted that bleomycin and middotolin could be highly sensitive to samples with high TIMP1 expression.Conclusion:TIMP1 is expected to be a new predictive biomarker to identify the benefits of cancer immunotherapy,and bleomycin and middotolin may be potential individualized treatment options for patients with high expression of TIMP1.
