Clinical Study on Tongfu Xiere Quyu Shuli Prescription in the Treatment of Functional Dyspepsia of Spleen and Stomach Damp-Heat and Qi Stagnation and Blood Stasis Type
10.14148/j.issn.1672-0482.2025.0961
- VernacularTitle:通腑泄热祛瘀疏利方治疗脾胃湿热兼气滞血瘀型功能性消化不良的临床研究
- Author:
Mingli WANG
1
;
Pengcheng SONG
1
;
Haiyan ZHANG
1
;
Ling ZHOU
1
;
Weiguo ZHAO
1
;
Nannan WANG
1
;
Na YANG
1
Author Information
1. 衡水市人民医院中医科,河北 衡水 053000
- Publication Type:Journal Article
- Keywords:
functional dyspepsia;
spleen and stomach damp-heat syndrome;
qi stagnation and blood stasis syndrome;
Professor Li Bingmao;
Tongfu Xiere Quyu Shuli Prescription;
clinical efficacy;
intestinal flora;
gastrointestinal hormones
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2025;41(7):961-968
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study the clinical efficacy of Professor Li Bingmao's Tongfu Xiere Quyu Shuli Prescription in the treatment of patients with functional dyspepsia(FD)of spleen and stomach damp-heat and qi stagnation and blood stasis type.METH-ODS A total of 206 patients with functional dyspepsia of spleen and stomach damp-heat and qi stagnation and blood stasis type diag-nosed by Hengshui People's Hospital were included in the study and randomly divided into a study group and a control group with 103 cases in each group.During the treatment,3 cases dropped out in each group.The control group adopted the conventional Western medicine treatment plan for functional dyspepsia(mosapride+rabeprazole),and the study group took Tongfu Xiere Quyu Shuli Pre-scription on the basis of the treatment of the control group.The treatment course of both groups was 4 weeks.The traditional Chinese medicine(TCM)syndrome scores,psychological status[self-rating anxiety scale(SAS),self-rating depression scale(SDS),and quality of life[Nepean dyspepsia life quality index(NDLQI)of the two groups of patients before and after treatment were observed and the clinical efficacy was evaluated;serum motilin(MTL),ghrelin,gastrin(GAS),corticotropin-releasing hormone(CRH)and pep-sinogen(PG Ⅰ,PG Ⅱ)were measured by enzyme-linked immunosorbent assay;changes in gastric motility indexes were analyzed by electrogastrogram analyzer;changes in intestinal flora were detected by instillation method.The occurrence of adverse reactions in the two groups of patients was monitored during treatment.RESULTS After treatment,the TCM syndrome scores of the two groups were significantly reduced(P<0.05,P<0.01),and the score in the study group was lower than that in the control group(P<0.01).The total effective rate of the study group was significantly higher than that in the control group(P<0.01).After treatment,the expression levels of MTL,Ghrelin,GAS,PG Ⅰ and PG Ⅱ in the two groups increased,and CRH decreased,and the improvement degree of the study group was better than that of the control group(P<0.01).After treatment,the main frequency and slow wave percentage of the electrogastrogram increased in the two groups,and the study group was better than that of the control group(P<0.01).After treat-ment,the number of bifidobacteria and lactobacilli in the two groups increased,and the number in the study group was greater than that in the control group,while the number of enterobacteria,enterococci and yeast decreased,and the number in the study group was less than that in the control group(P<0.01).There was no significant difference in adverse reactions between the two groups(P>0.05).CONCLUSION Tongfu Xiere Quyu Shuli Prescription is effective in the treatment of FD patients with spleen and stomach damp-heat syndrome,and can improve FD clinical symptoms,quality of life,anxiety and depression symptoms,regulate gastrointesti-nal hormone expression levels,gastric motility and intestinal flora expression,and does not increase adverse reactions,and is safe and reliable.
