Correlation between cognitive impairment and depression in elderly patients with type 2 diabetes mellitus
10.3969/j.issn.1009-0126.2025.04.007
- VernacularTitle:老年2型糖尿病患者认知障碍与抑郁的相关性研究
- Author:
Yuanyuan ZHAN
1
;
Xinyue XU
;
Bowen LU
;
Muxin ZHANG
;
Fangbo CHEN
;
Jie FENG
;
Qingrong PAN
;
Zhe CHEN
Author Information
1. 100020 首都医科大学附属北京朝阳医院内分泌科
- Publication Type:Journal Article
- Keywords:
diabetes mellitus,type 2;
depression;
cognition disorders;
loneliness
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(4):426-430
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between cognitive impairment and depression in elderly patients with type 2 diabetes mellitus(T2DM).Methods Based on China Health and Retirement Longitudinal Study in 2011,totally 521 elderly T2DM patients were enrolled,and according to the results of minimum mental state examination(MMSE)and their education lev-els,they were divided into a cognitively impaired group(437 cases)and a cognitively normal group(84 cases).Center for ED Epidemiological Survey Depression Scale was used to assess the depression symptoms.The correlation between cognitive impairment and depression was analyzed.Results Compared with the cognitively normal group,the cognitively impaired group had signifi-cantly advanced age(71.98±5.29 year vs 69.42±3.98 year,P=0.000),larger proportion of de-pression(60.6％vs 35.7％,P=0.000),and higher C-reactive protein level(5.09±12.80 mg/L vs 2.25±2.43 mg/L,P=0.000),and obviously lower ratios of being married(72.1％vs 86.9％,P=0.001)and having cardiovascular disease(20.1％vs 32.1％,P=0.010),and decreased estimated glomerular filtration rate[77.15±15.88 ml/(min·1.73 m2)vs 81.91±13.55 ml/(min·1.73 m2),P=0.001].Multivariate logistic regression analysis showed that cognitive impairment was an independent risk factor for the development of depression in elderly T2DM patients(OR=3.44,95％CI:1.89-6.27,P＜0.01).ROC curve analysis indicated that the AUC value of MMSE score in predicting depression in elderly T2DM patients was 0.669(95％CI:0.626-0.709,P＜0.01).The direct effect of cognitive impairment and the mediating effect of loneliness on depression in elderly T2DM patients accounted for 72.22％and 27.78％of the total effect,respectively.Conclu-sion Cognitive impairment is associated with the presence of depression in elderly T2DM pa-tients,and loneliness plays a mediating role.
