Associations of high-sensitivity C-reactive protein and T cells with cognitive impairment
10.3969/j.issn.1009-0126.2025.04.003
- VernacularTitle:高敏C反应蛋白及免疫T细胞与认知障碍的相关性
- Author:
Xianzhi YANG
1
;
Shu ZHANG
1
;
Xuexuan GU
1
;
Mingqing WEI
1
;
Ting LI
1
;
Jingnian NI
1
;
Jing SHI
1
;
Jinzhou TIAN
1
Author Information
1. 100007 北京中医药大学东直门医院脑病科三区
- Publication Type:Journal Article
- Keywords:
cognition disorders;
CD8-positive T-lymphocytes;
C-reactive protein
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(4):408-411
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the associations of immune cells,CD8+and CD4+T cells,and high-sensitivity C-reactive protein(hs-CRP)with cognitive function,and to explore the relation-ships among immunity,chronic inflammation,and Alzheimer's disease-related cognitive impair-ment.Methods A cross-sectional study was conducted on 101 patients with primary complaints of memory decline who visited the Alzheimer's Disease Clinic of Dongzhimen Hospital from June to December 2024.Mini-Mental State Examination(MMSE)and Delayed Story Recall Task(DSR)were performed to assess their cognitive function,and according to the results,they were divided into observation group(cognitively impaired,60 cases)and control group(cognitively normal,41 cases).Peripheral blood levels of CD8+T cells,CD4+T cells,and hs-CRP were compared between the two groups.Results The observation group exhibited significantly lower total scores and scores of different dimensions of MMSE and DSR scores,but notably higher activities of daily liv-ing scores than the control group(P＜0.05,P＜0.01).Serum hs-CRP level was obviously elevated in the observation group than the control group(P＜0.05).Binary logistic regression analysis revealed that CD8+T cells(OR=0.998,95％CI:0.996-1.000,P=0.038)and body mass index(OR=0.843,95％CI:0.719-0.990,P=0.037)were protective factors,while hs-CRP(OR=2.004,95％CI:1.215-3.306,P=0.006)was an independent risk factor for cognitive impairment.Spearman's rank correlation analysis showed a significant positive correlation between hs-CRP and CD4+T cells(P=0.011),but no significant association with CD8+T cells(P＞0.05).Conclusion Chronic inflammation and immune dysregulation synergistically contribute to cogni-tive decline.Hs-CRP may serve as a potential screening biomarker for cognitive impairment in pri-mary care settings.
