Research progress on region-specific synaptic plasticity in the central nervous system involved in morphine tolerance
10.3969/j.issn.1006-5725.2025.13.023
- VernacularTitle:中枢神经系统区域特异性突触可塑性参与吗啡耐受的研究进展
- Author:
Yajie HAN
1
;
Jian WANG
1
;
Zongbin SONG
1
Author Information
1. 中南大学湘雅医院麻醉科(湖南 长沙 410008)
- Publication Type:Journal Article
- Keywords:
morphine tolerance;
synapse;
functional plasticity;
structural plasticity;
central nervous system
- From:
The Journal of Practical Medicine
2025;41(13):2100-2104
- CountryChina
- Language:Chinese
-
Abstract:
The repeated administration of morphine frequently gives rise to tolerance,manifested by a reduction in analgesic efficacy and an elevation in adverse effects.These consequences significantly impinge upon its clinical utility.Synaptic functional plasticity governs long-term alterations in synaptic transmission efficiency through calcium signaling pathways,protein kinase cascade reactions,and glia-neuron interactions,thereby facili-tating the development of morphine tolerance.Structural plasticity encompasses the dynamic remodeling of dendritic spine density and morphology,the establishment or elimination of synaptic connections,and the reconstitution of synaptic active zones.Morphine-induced synaptic plasticity within the central nervous system demonstrates region-specific alterations,which jointly drive the process of tolerance.This review comprehensively synthesizes the research advancements regarding the mechanisms of synaptic plasticity in morphine tolerance,with the aim of furnishing a theoretical foundation for the development of innovative analgesic medications and the optimization of clinical treatment strategies.
