Research progress on the role of invariant natural killer T cells in immune-mediated liver injury
10.3760/cma.j.cn501113-20240429-00235
- VernacularTitle:固有性自然杀伤细胞功能在免疫介导肝损伤中作用的研究进展
- Author:
Lixin BAI
1
;
Wankun HAO
;
Jingrui LI
;
Shaofei LI
;
Liting ZHANG
;
Junfeng LI
Author Information
1. 兰州大学第一临床医学院，兰州 730000
- Publication Type:Journal Article
- Keywords:
Autoimmune hepatitis;
Immune-mediated liver injury;
Invariant Natural Killer T cells;
Glycosphingolipid;
Therapeutic
- From:
Chinese Journal of Hepatology
2025;33(3):273-279
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of immune-mediated liver injury is related to immune regulation disorders. In recent years, researchers have focused on the unique role of invariant natural killer T cells (iNKT cells) in immune-mediated liver injury. iNKT cells, a special subset of lymphocytes, are crucial for immune regulation by bridging innate and adaptive immunity. iNKT cells interact with various immune cells and possess strong immune regulatory capabilities, but their role is complex, potentially promoting liver injury or protecting the liver from damage. This article reviews the latest research progress on iNKT cells in immune-mediated liver injury and describes some factors that regulate immune liver injury by altering the expression of glycosphingolipids, such as liver X receptor and tumor progression site2. In addition, the research results are explored to assist in deepening the understanding of the mechanism of immune-mediated liver injury so as to provide new directions for the development of related treatment strategies.
