Relationship between cognitive function and sleep quality in Alzheimer's disease
10.3969/j.issn.1009-0126.2025.04.010
- VernacularTitle:阿尔茨海默病认知功能与睡眠质量关系的探讨
- Author:
Yan YAN
1
;
Junlei ZHANG
1
;
Jingnian NI
1
;
Ting LI
1
;
Jing SHI
1
;
Jinzhou TIAN
1
;
Mingqing WEI
1
Author Information
1. 100700 北京中医药大学东直门医院脑病三科
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
sleep disorders;
cognition;
correlation of data
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(4):440-444
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between cognitive function and sleep quality in patients with Alzheimer's disease(AD).Methods A case-control trial was conducted on 151 patients admitted to our department from May 2024 to December 2024.The patients with mild-to-moderate AD were assigned into the AD group(59 cases),and the cognitively normal patients in-to the control group(92 cases).All patients received neuropsychological assessment and sleep quality evaluation,including mini-mental state examination(MMSE),Montreal cognitive assess-ment(MoCA)and Pittsburgh sleep quality index(PSQI).The general clinical data and sleep qual-ity were compared between the two groups.Spearman correlation analysis was applied to analyze the relationship between cognitive function and sleep quality in the AD patients.Results The education level,MMSE score,MoCA score,instant story recall(ISR)score,delayed story recall(DSR)score,clock dawning test(CDT)score and Boston naming test score were significantly lower,while the activity of daily living(ADL)score was obviously higher in the AD group than the cognitively normal group(P＜0.05,P＜0.01).The AD patients had notably higher total score of PSQI and scores of sleep efficiency,nocturnal sleep disturbance and daytime dysfunction than the cognitively normal patients(P＜0.05,P＜0.01).In the AD patients,the total sleep time was positively correlated with the DSR score and the CDT score(r=0.300,P=0.021;r=0.308,P=0.018);hypnotic medication was negatively correlated with MMSE score,ISR score,and DSR score,and positively with ADL score(r=-0.320,P=0.013;r=-0.400,P=0.002;r=-0.331,P=0.010;r=0.355,P=0.006).Multiple linear regression analysis showed that benzodiazepines use and education level were independent influencing factors for cognitive function in the AD patients(P＜0.05,P＜0.01).Conclusion In AD patients,sleep quality is closely associated with cognitive function,as manifested by decreased sleep quality,reduced sleep efficiency,and worsened nocturnal sleep disturbances and daytime dysfunction.Administration of benzodiazepines may exacerbate cognitive impairment in AD patients.So,it is recommended that AD patients should be cautious about taking such drugs.
