Exploration of the relationship between patients with MAFLD and MetALD for alcohol intake on all-cause mortality based on NHANES Ⅲ data
10.3760/cma.j.cn501113-20241018-00547
- VernacularTitle:基于NHANES Ⅲ数据探究饮酒量与代谢相关脂肪性肝病及代谢和酒精相关性肝病患者全因死亡率的关系
- Author:
Leyao JIA
1
;
Fajuan RUI
;
Xiangyu WU
;
Sisi ZHOU
;
Yijie CHEN
;
Chao WU
;
Junping SHI
;
Weihua WU
;
Jie LI
Author Information
1. 南京医科大学鼓楼临床医学院感染性疾病科，南京 210008
- Publication Type:Journal Article
- Keywords:
Metabolic associated fatty liver disease;
Metabolic and alcohol-associated liver disease;
Alcohol intake;
Diabetes mellitus type 2;
All-cause mortality
- From:
Chinese Journal of Hepatology
2025;33(9):862-871
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the impact of evaluating the alcohol intake on all-cause mortality in patients with metabolic-associated fatty liver disease（MAFLD）and metabolic dysfunction and alcohol-related liver disease（MetALD）.Method:The retrospective study included patients aged 20 to 74 years with hepatic steatosis diagnosed by ultrasound，with data from the Third National Health and Nutrition Examination Survey（NHANES III）between 1988 and 1994. Participants were categorized into light，moderate，and heavy drinking groups according to daily alcohol intake. Multivariable-adjusted hazard ratios（aHR）and their 95% confidence intervals（ CI）were calculated by Cox proportional risk regression modeling to assess the effect of alcohol intake on all-cause mortality. Results:A total of 2 322 patients were included in the study. Males accounted for 50.2%（1 166/2 322），with a age of 42.0（31.3，57.0）years，a median follow-up of 316.0（270.0，337.0）months，and an all-cause mortality rate of 1.48% per person-year. There were 1，763 cases in the light drinking group，333 in the moderate drinking group，and 226 in the heavy drinking group.The all-cause mortality rates for patients in the three drinking groups were 1.38%，1.67%，and 2.10% per person-year，respectively. The moderate（a HR=1.37，95% CI：1.12 to 1.67， P=0.002）and heavy（a HR=1.45，95% CI：1.17 to 1.80， P=0.001）drinking groups were independently associated with increased all-cause mortality following covariate adjustment. There was a difference in all-cause mortality for alcohol intake in non-type 2 diabetes mellitus（T2DM）patients under 60 years of age（ P<0.05），but the difference was not statistically significant between non-T2DM patients over 60 years of age and T2DM patients of all ages（ P>0.05）according to the analysis of diabetes status and age subgroups. Conclusion:Alcohol intake has a dose-dependent negative effect on patients with MAFLD and MetALD. The risk of all-cause mortality increased significantly with increasing alcohol intake.
