Research progress on the mechanistic role and constituents of hepatic macrophages during the occurrence and development of hepatic fibrosis
10.3760/cma.j.cn501113-20240103-00006
- VernacularTitle:肝纤维化发生和发展过程中肝脏巨噬细胞组成及其作用机制的研究进展
- Author:
Ruixi LIU
1
;
Jinfang LIU
;
Ping XU
Author Information
1. 军事科学院军事医学研究院 医学蛋白质组全国重点实验室 国家蛋白质科学中心（北京）北京蛋白质组研究中心，北京 102206
- Publication Type:Journal Article
- Keywords:
Liver fibrosis;
Macrophage;
Single-cell RNA sequencing;
Antifibrotic;
Therapeutic
- From:
Chinese Journal of Hepatology
2025;33(2):198-204
- CountryChina
- Language:Chinese
-
Abstract:
Macrophages are the key cells in the process of hepatic fibrosis. Therefore, they promote the progression and regression of liver fibrosis by participating in all stages. The treatment of liver fibrosis is significantly identified by the main subtypes of intrahepatic macrophages. This article summarizes the types and functions of macrophages according to the inflammatory phenotype, origin, and surface markers and their effect on fibrosis; introduces the new subtypes and mode of action in the occurrence and development of hepatic fibrosis, as revealed by the single-cell sequencing technique; and analyzes the limitations of traditional antifibrotic therapy and the advantages of macrophage-targeting therapeutics, which could indicate the new direction for the study of new macrophage subtypes in hepatic fibrosis.
