Systemic immunoinflammatory index combined with ratio of C-reactive protein to albumin to evaluate prognosis of patients with non-small cell lung cancer
10.3969/j.issn.1000-484X.2025.07.010
- VernacularTitle:全身免疫炎症指数联合C反应蛋白/白蛋白对非小细胞肺癌的预后价值
- Author:
Haoxin GUO
1
;
Wenbo WU
;
Wenfei XUE
;
Dahu REN
;
Xiaopeng ZHANG
;
Guochen DUAN
Author Information
1. 河北省人民医院胸外二科,石家庄 050000;河北医科大学,石家庄 050000
- Publication Type:Journal Article
- Keywords:
Systemic immune inflammatory index;
C-reaction protein to albumin ratio;
Non-small cell lung cancer
- From:
Chinese Journal of Immunology
2025;41(7):1605-1609
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate whether systemic immune inflammation index(SII)-C-reactive protein/albumin(CRP/Alb)can predict postoperative survival in non-small cell lung cancer(NSCLC)patients.Methods:A total of 262 patients with NSCLC who underwent surgery in Hebei Provincial People's Hospital from January 2017 to November 2020 were included.SII and CRP/Alb expressions in patients after surgery were analyzed by K-M survival curve analysis,Cox multivariate risk regression analysis and ROC curve analysis.Results:Patients with high SII expression(>961.78)and high CRP/Alb expression(>0.025)had worse outcomes than patients with low SII and CRP/Alb expressions,respectively(P<0.001).SII-CRP/Alb score(P=0.032),age≥60 years(P=0.038)and T stage T2～T3(P<0.001)were significantly associated with shorter overall survival.AUC of SII-CRP/Alb scores were larger than SII and CRP/Alb scores,respectively.Conclusion:SII-CRP/Alb score can effectively evaluate postoperative survival status of patients with NSCLC,and SII-CRP/Alb score are independent predictors of postoperative overall survival in NSCLC patients.
