Clinical case analysis of an autoimmune glial fibrillary acidic protein astrocytopathy
10.3969/j.issn.1000-484X.2025.07.033
- VernacularTitle:一例自身免疫性胶质纤维酸性蛋白星形胶质细胞病的临床病例分析
- Author:
Xiaoyan WANG
1
;
Zhong ZHAO
1
;
Wenli CHEN
1
;
Niya WANG
1
;
Hao TANG
1
Author Information
1. 云南省第一人民医院暨昆明理工大学附属医院,昆明 650032
- Publication Type:Journal Article
- Keywords:
Anti-GFAP antibody;
Autoimmune encephalitis;
Meningitis;
Cranial MRI
- From:
Chinese Journal of Immunology
2025;41(7):1768-1771
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summarize the clinical characteristics of autoimmune glial fibrillary acidic protein astrocytopathy(GFAP-A),in order to improve the understanding of the disease among clinical physicians.Methods:A retrospective analysis was conducted on the clinical manifestations,imaging examination,laboratory examination of a patient with GFAP-A who was admitted to the First People's Hospital of Yunnan Province and diagnosed on May 11,2023.Results:A female patient with GFAP-A,aged 67 years,presented with meningoencephalomyelitis.The head MRI showed abnormalities,with extensive lesions in the bilateral basal ganglia,pons,and lateral paraventricular white matter areas,and enhancement of the lateral ventricular ependyma and pia mater.Long segment spinal cord abnormal signals were observed,and cerebrospinal fluid anti GFAP antibodies were positive.After hormone treatment,the prognosis was good,and there was no recurrence during follow-up.Conclusion:The main clinical manifestations of GFAP-A are acute or subacute onset meningitis and/or encephalitis,myelitis and meningitis.Detection of autoimmune antibodies in ce-rebrospinal fluid can provide a clear diagnosis,and timely treatment can improve prognosis.
