Research progress on B cells in chronic hepatitis B
10.3760/cma.j.cn501113-20240809-00370
- VernacularTitle:慢性乙型肝炎中B细胞研究进展
- Author:
Lili TANG
1
;
Ruonan XU
1
;
Fusheng WANG
1
Author Information
1. 解放军总医院第五医学中心感染病医学部，北京 100039
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Chronic hepatitis B;
B cells;
Antigen specific
- From:
Chinese Journal of Hepatology
2025;33(2):186-190
- CountryChina
- Language:Chinese
-
Abstract:
B cells play a key role in humoral immunity and participate in the clearance of hepatitis B virus (HBV) through antibody production, antigen presentation, and immune regulation. Variations in immunological responses to different HBV antigens show antigenic heterogeneity in B cells during HBV infection. In recent years, it has been found that hepatitis B surface antibody-specific B cells are abnormally differentiated, while hepatitis B core antibody-specific B cells are relatively intact in patients with chronic hepatitis B (CHB). Additionally, defects in the non-antibody-generating functions of B cell lead to persistent HBV infection. This article provides important insights for understanding the role and function of B cells in chronic HBV infection and a scientific basis for the development of novel therapeutic strategies..
