Plasma CTRP6 and SIRI levels in patients with heart failure and their clinical significance
10.3969/j.issn.1673-9701.2025.09.007
- VernacularTitle:心力衰竭患者血浆CTRP6、SIRI水平及临床意义
- Author:
Jiahui MA
1
;
Zhong WANG
Author Information
1. 石河子大学医学院,新疆石河子 832003
- Publication Type:Journal Article
- Keywords:
C1q/tumor necrosis factor-related protein 6;
Systemic inflammation response index;
Heart failure;
Left ventricular remodeling;
Left ventricular ejection fraction
- From:
China Modern Doctor
2025;63(9):29-32,46
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the plasma levels of C1q/tumor necrosis factor-related protein 6(CTRP6)and systemic inflammation response index(SIRI)in patients with heart failure(HF)and their clinical significance.Methods 126 HF patients admitted to the Heart Center,the First Affiliated Hospital of Shihezi University from October 2023 to September 2024 were selected and divided into heart failure with reduced ejection fraction(HFrEF)group(n=43),heart failure with mildly reduced ejection fraction(HFmrEF)group(n=45)and heart failure with preserved ejection fraction(HFpEF)group(n=38)according to left ventricular ejection fraction(LVEF)value.Non-HF patients treated at the same period were selected as the control group(n=38).Blood routine,N-terminal pro-B-type natriuretic peptide(NT-proBNP)and echocardiogram parameters were collected,SIRI and left ventricular mass index(IVMI)were calculated,plasma CTRP6 levels were detected by enzyme-linked immunosorbent assay,and the correlation between CTRP6,SIRI and LVEF,IVMI,NT-proBNP and New York Heart Association grades in HF patients was analyzed.Risk factors of HF were analyzed by Logistic regression analysis and receiver operating characteristic(ROC)curve was drawn.Results Compared with control group,HF patients showed statistically significant increases in creatinine,uric acid,estimate glomerular filtration rate,and SIRI levels,as well as a higher proportion of patients with coronary heart disease and atrial fibrillation.Conversely,CTRP6 levels were decreased,with statistical significance(P＜0.05).There were statistical differences in CTRP6,NT-proBNP,LVEF and IVMI of HF patients with different ejection fraction classification(P＜0.05).Spearman correlation analysis showed that CTRP6 level was positively correlated with LVEF and negatively correlated with LVMI in HF patients.SIRI was positively correlated with NT-proBNP and negatively correlated with LVEF.Logistic regression analysis indicates that CTRP6 is independent protective factor for HF,and a decrease in CTRP6 is an independent risk factor for HF severity.The area under ROC curve of CTRP6,SIRI and their combined diagnosis HF are 0.762,0.772 and 0.850,respectively.Conclusion The plasma CTRP6 level in HF patients is significantly decreased,and SIRI is significantly increased.Both of them have good diagnostic value for HF patients,and their combined detection can improve the diagnostic efficiency.
