Are antibiotics immunomodulators? An attempt to use vancomycin in the treatment of primary sclerosing cholangitis
10.3760/cma.j.cn501113-20240424-00225
- VernacularTitle:万古霉素在原发性硬化性胆管炎治疗中的尝试：抗生素亦是免疫调节剂
- Author:
Liping GUO
1
;
Weirong WANG
1
;
Bangmao WANG
1
;
Lu ZHOU
1
Author Information
1. 天津医科大学总医院消化内科，天津 300052
- Publication Type:Journal Article
- Keywords:
Primary sclerosing cholangitis;
Vancomycin;
Intestinal flora;
Bile acid metabolism;
Immunoregulation
- From:
Chinese Journal of Hepatology
2025;33(3):287-292
- CountryChina
- Language:Chinese
-
Abstract:
Primary sclerosing cholangitis (PSC) is a type of chronic idiopathic liver disease characterized by bile duct inflammation and concentric fibrosis. Currently, no drug therapy can change the natural progression of PSC. The mechanism by which PSC is accompanied by the occurrence of inflammatory bowel disease (IBD) is still unclear. Oral antibiotic therapy with vancomycin being the most widely used has been shown to be effective for PSC combined with IBD. This paper analyzes case reports and clinical studies on the use of vancomycin in PSC, with the aim of providing a reference for clinical therapy and in-depth exploration of novel therapeutic directions.
