Mendelian randomization study on gut microbiota and pituitary adenoma
10.3969/j.issn.1673-9701.2025.09.006
- VernacularTitle:肠道菌群与垂体腺瘤的孟德尔随机化研究
- Author:
Ting HE
1
;
Jianlie YUAN
Author Information
1. 浙江大学医学院,浙江 杭州 310029
- Publication Type:Journal Article
- Keywords:
Pituitary adenoma;
Gut microbiota;
Mendelian randomization analysis;
Inverse variance weighted
- From:
China Modern Doctor
2025;63(9):24-28
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the potential causal relationship between gut microbiota and pituitary adenoma(PA).Methods Two-sample Mendelian randomization(MR)analysis was adopted by using genome wide association study(GWAS)summary statistics from the MiBioGen consortiums(obtaining 211 gut microbiota taxa)and FinnGen consortiums R9 release data(from 1402 cases PA patients and 375 875 control cases)to evaluate the causal association between gut microbiota and PA.Inverse variance weighted method was used as main analysis method,and pleiotropy and heterogeneity tests were used to verify the reliability of the results.In addition,a reverse MR analysis was performed to rule out the possibility of a reverse causal association.Results Genus Ruminococcaceae UCG004(OR=1.391,95％CI:1.004-1.932,P=0.049),Fusicatenibacter(OR=1.654,95％CI:1.101-2.494,P=0.017),and family Acidaminococcaceae(OR=1.994,95％CI:1.252-3.173,P=0.004)were found to increase the risk of PA.Conversely,the genus Ruminiclostridium 5(OR=0.634,95％CI:0.415-0.991,P=0.043),genus Eisenbergiella(OR=0.701,95％CI:0.551-0.915,P=0.007),class Negativicutes(OR=0.574,95％CI:0.362-0.895,P=0.014),and phylum Euryarchaeota(OR=0.784,95％CI:0.644-0.975,P=0.022)exhibited a negative correlation with PA.Sensitivity analyses indicated the absence of pleiotropy and heterogeneity.Conclusion The causal relationship between gut microbiota and PA may provide a new theoretical basis for the pathogenesis of PA.
