Current status and prospects of botulinum toxin type-A combined with platelet-rich plasma injection

VernacularTitle:A型肉毒毒素联合富血小板血浆注射的应用现状及展望
Author: Siqing WANG ¹ ; Ningjie CHEN ; Haitao WANG ; Qingpeng XU ; Doudou CHAI ; Shuang YAN
Author Information

1. 滨州医学院第二临床医学院，烟台　264003
Publication Type:Journal Article
Keywords: Platelet-rich plasma; Botulinum toxin type-A; Synergism; Antagonism
From: Chinese Journal of Medical Aesthetics and Cosmetology 2025;31(5):451-456
CountryChina
Language:Chinese
Abstract: In recent years, botulinum toxin type-A (BTX-A) combined with cosmetic injections and radiofrequency lasers have been widely implemented to achieve better tissue repair. Among these therapies, platelet-rich plasma (PRP), rich in growth factors, has demonstrated notable efficacy in promoting tissue regeneration and repair. However, there is some controversy regarding the combined use of these two biomaterials in the treatment of various diseases. This review summarizes the current status of their combined application in peripheral neuropathic pain, seborrheic alopecia, and facial rejuvenation, also analyzes the advantages, interactions, and influencing factors of the combined application. Although the effectiveness and safety of PRP combined with BTX-A injection therapy in many of the above diseases are relatively high, the conclusion should still be carried out in the future multi-center, large-sample clinical studies to improve the credibility and representativeness of the results.