Types of injectable drugs and mechanisms of intralesional injection therapy for keloid
10.3760/cma.j.cn114657-20241025-00151
- VernacularTitle:瘢痕疙瘩病灶内注射治疗药物的种类及作用机制
- Author:
Haiyu DU
1
;
Ning LI
Author Information
1. 连云港市第二人民医院烧伤整形科，连云港 222023
- Publication Type:Journal Article
- Keywords:
Keloid;
Pathological scar;
Fibroblasts;
Intralesional injection;
Treatment
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2025;31(5):445-450
- CountryChina
- Language:Chinese
-
Abstract:
Keloid is a benign skin fiber proliferative disease caused by abnormal repair of skin injury, characterized by lesions that often exceed the boundaries of the original injury and infiltrate into the surrounding adjacent normal skin. Keloid scars not only cause pain, itching and other symptoms, but also cause aesthetic defects, bringing great psychological burden to patients. The treatment of keloid is divided into surgical treatment and non-surgical treatment. The non-surgical treatment is most commonly used with drug injection, which has the advantages of less traumatic, simple operation, low recurrence rate, and high patient tolerance compared with surgical treatment. In recent years, with the deepening of the research on the pathogenesis of keloid, the drug injection treatment of keloid has also made great progress, including glucocorticoids, botulinum toxin type A, antitumor drugs, verapamil, interferon, vitamin D, platelet-rich plasma, and other drugs under development, including adipose-derived stem cells, mTOR signaling pathway inhibitors, renin-angiotensin system modulators, and lipocalins. In this article, the types of injectable drugs and mechanisms for the treatment of keloid are summarized, with a view to providing some reference for clinical treatment.
