Stability of salvianolic acid B based on degradation kinetic models
10.3969/j.issn.1001-1528.2025.03.005
- VernacularTitle:基于降解动力学模型的丹酚酸B稳定性研究
- Author:
Wen-kang LIU
1
;
Xian-run HU
;
Xue-mei CHENG
;
Wei LIU
;
Hai WEI
;
Chang-hong WANG
Author Information
1. 上海中医药大学中药研究所,中药标准化教育部重点实验室,上海市复方中药重点实验室,上海 201203;上海中医药大学交叉科学研究院,上海 201203
- Publication Type:Journal Article
- Keywords:
salvianolic acid B;
stability;
degradation kinetics;
HPLC
- From:
Chinese Traditional Patent Medicine
2025;47(3):733-739
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the stability of salvianolic acid B.METHODS HPLC was adopted in the content determination of salvianolic acid B,after which the chemical stability in different pH of buffer solutions,oxidation stability in different concentrations of H2O2,and biological stability in artificial gastric fluid,artificial intestinal fluid and biological matrices were analyzed,and its degradation kinetics was fitted.RESULTS Salvianolic acid B was stable in acidic and weakly acidic buffer solutions and artificial gastric fluid,which demonstrated poor stability in neutral and alkaline buffer solutions,artificial intestinal fluid,H2O2 and biological matrices.The degradation process of this constituent accorded with the first-order kinetic model in ileum homogenate,and the second-order kinetic model in pH 7.4 buffer solution,artificial intestinal fluid,H2O2 and stomach,duodenum,jejunum,colon homogenates.CONCLUSION Biological matrices,oxidants and alkaline environment can affect the stability of salvianolic acid B.This experimental exhibits important significance for the development and application of salvianolic acid B-related products.
