Efficacy and safety of needle knife combined with local injection of compound betamethasone in treatment of truncal keloids
10.3760/cma.j.cn114657-20241230-00223
- VernacularTitle:针刀联合复方倍他米松局部注射治疗躯干部瘢痕疙瘩的疗效与安全性分析
- Author:
Dongjie SUN
1
;
Mingqiang SHEN
1
;
Liliang XU
1
;
Jing XIE
1
Author Information
1. 杭州师范大学附属医院烧伤整形科，杭州 310000
- Publication Type:Journal Article
- Keywords:
Keloid;
Compound betamethasone;
Needle-knife;
Efficacy
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2025;31(6):605-610
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the efficacy and safety of needle knife combined with local injection of compound betamethasone in the treatment of truncal keloids.Methods:A total of 56 patients with truncal keloids were prospectively enrolled from the Affiliated Hospital of Hangzhou Normal University from May 2022 to May 2024. Among them, there were 27 males and 29 females, aged 20-45 (31.5±6.6) years. The disease duration was 12.0 (9.0, 14.0) months. The area of keloids was (6.9±3.0) cm2, and the thickness was (3.8±0.7) mm. The 56 patients had a total of 62 truncal keloids. The etiological factors included injury or surgery (26 keloids), infection (6 keloids), and unknown causes (30 keloids). The locations of keloids were the chest (43 keloids), abdomen (11 keloids), and shoulders/back (8 keloids). Patients were divided into experimental group and control group using a random number table. The experimental group (27 patients with 29 keloids) received combined treatment of local compound betamethasone injection and needle knife therapy. The control group (29 patients with 33 keloids) received local compound betamethasone injection only. The Vancouver scar scale (VSS) was used to score keloids before the treatment and at 1, 3, 6 months after the treatment. Meanwhile, patients were instructed to score the pain and pruritus symptoms of their keloids using the visual analogue scale (VAS). At 6 months after the start of treatment, the incidence of adverse reactions and recurrence rate were calculated, and patient satisfaction was evaluated.Results:Intra-group comparison showed that the VSS and VAS scores of both groups at 1, 3, 6 months after the treatment were statistically significantly different from those before the treatment (all P<0.05). Inter-group comparison revealed no statistically significant differences in VSS and VAS scores between the two groups before the treatment (all P>0.05). At 1 month after the treatment, there was no statistically significant difference in VSS scores between the two groups ( P=0.515), but the VAS score of the experimental group was lower than that of the control group ( P=0.008). At 3 and 6 months after the treatment, both VSS and VAS scores of the experimental group were lower than those of the control group (all P<0.05). In the experimental group, 1 case of hypopigmentation occurred, with an adverse reaction rate of 3.4% (1/29). In the control group, 1 case of hypopigmentation and 1 case of mild depression occurred, with an adverse reaction rate of 6.1% (2/33); the difference between the two groups was not statistically significant ( P=1.000). The recurrence rates of the experimental group and the control group were 58.6% (17/29) and 69.7% (23/33), respectively, with no statistically significant difference ( P=0.363). The satisfaction scores of the experimental group and the control group were (85.6±6.7) and (78.3±9.4) scores, respectively, and the difference was statistically significant ( P=0.002). Conclusion:Needle knife combined with local injection of compound betamethasone has good efficacy in the treatment of truncal keloids, with a low incidence of adverse reactions and high patient satisfaction.
