Research progress of tolvaptan in the treatment of refractory ascites in cirrhosis
10.3760/cma.j.cn501113-20231225-00299
- VernacularTitle:托伐普坦治疗肝硬化难治性腹水的研究进展
- Author:
Qingqing ZHANG
1
;
Yue CHEN
1
;
Yixiong CHEN
1
;
Ling YANG
1
Author Information
1. 华中科技大学同济医学院附属协和医院消化内科，武汉 430022
- Publication Type:Journal Article
- Keywords:
Liver cirrhosis;
Therapeutic;
Refractory ascites;
Tolvaptan;
Mechanisms;
Efficacy;
Safety;
Predictive factors
- From:
Chinese Journal of Hepatology
2025;33(1):88-92
- CountryChina
- Language:Chinese
-
Abstract:
Ascites is the most common complication in the decompensated stage of cirrhosis, with approximately 5% to 10% progressing to refractory ascites (RA). The complex pathogenesis, difficult treatment, and poor prognosis are major challenges and difficulties in the clinical treatment of RA. Tolvaptan (TLV) is a kind of novel non-peptide, selective arginine vasopressin V2 receptor antagonist that can inhibit renal water reabsorption, promote free water excretion, and increase blood sodium levels, providing a new clinical option for the treatment of cirrhotic RA. This paper briefly summarizes the mechanism of action of TLV and introduces its effectiveness, safety, and predictive factors response in order to provide a reference for clinical application in the treatment of cirrhotic RA.
