Applications of mussel adhesive protein in dermatology: current status and prospects
10.3760/cma.j.cn114657-20250106-00004
- VernacularTitle:贻贝黏蛋白在皮肤领域的应用现状与展望
- Author:
He QIU
1
;
Zhijie LUO
;
Shiqi NONG
;
Yonghong LU
;
Hang WANG
Author Information
1. 四川大学华西口腔医院医疗美容科，成都 610041
- Publication Type:Journal Article
- Keywords:
Mussel adhesive protein;
Skin field;
Application progress
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2025;31(6):569-574
- CountryChina
- Language:Chinese
-
Abstract:
Mussel adhesive protein (MAP) is increasingly utilized in the biomedical field for the development of various bio-inspired products such as adhesives, protective films, and coatings with diverse properties, owing to its excellent biocompatibility, low immunogenicity, broad-spectrum adhesiveness, and biodegradability. The biological effects and mechanisms of MAP include adhesive film formation, cell migration and proliferation, anti-inflammatory and antioxidant activities, and inhibition of pigment formation. In dermatological applications, MAP demonstrates a significant potential in antibacterial and antipruritic effects, wound healing, barrier repair, and scar regeneration. In recent years, advances in understanding the secretion, distribution, and adhesion mechanisms of MAP, along with innovations in extraction methods, have led to the development of various natural MAP, recombinant MAP, mussel-inspired, and mussel-mimetic biomedical products. However, the biosafety, tissue compatibility, and functionality of these products remain subjects of debate. Further investigation is needed to elucidate the interactions between MAP-based products and various organ tissues and cells within complex biological systems, as well as to thoroughly evaluate their safety and efficacy. Such efforts are essential to achieve high-value utilization of MAP and to explore broader application prospects. Future research may focus on integrating MAP with emerging technologies such as nanotechnology and smart materials to further develop its multifunctional applications in the field of dermatology.
