Efficacy and safety of CO 2 fractional laser combined with botulinum toxin type-A in treatment of keloid
10.3760/cma.j.cn114657-20241104-00169
- VernacularTitle:CO 2点阵激光联合A型肉毒毒素注射治疗瘢痕疙瘩的疗效及安全性分析
- Author:
Wei WANG
1
;
Juanjuan BAI
1
;
Gaofeng ZHAO
1
Author Information
1. 郑州大学第一附属医院整形外科，郑州 450052
- Publication Type:Journal Article
- Keywords:
Lasers;
Botulinum toxin type-A;
Keloid
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2025;31(5):471-476
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect and safety of CO 2 fractional laser combined with botulinum toxin type-A (BTX-A) in the treatment of keloid. Methods:A total of sixty patients with keloids admitted to the First Affiliated Hospital of Zhengzhou University from December 2021 to September 2023 were prospectively included. The patients were divided into two groups using the random number table method: observation group (30 cases), including 12 males and 18 females, with an average age of (18.3±6.9) years, were treated with CO 2 fractional laser combined with Botox type A; control group (30 cases), including 13 males and 17 females, with an average age of (21.0±7.7) years, were treated with CO 2 fractional laser alone. The two groups received treatment once a month for 6 months. The total effective rate of the two groups after treatment were compared. The Vancouver scar scale (VSS) was used to evaluate the morphology of scars (including color, thickness, vascular distribution, and hardness) before and after treatment. Visual analog scale (VAS) was used to assess the degree of pain before and after treatment. The patient self-assessment (PSA) was used to evaluate the degree of itching before and after treatment. The incidence and recurrence of adverse reactions such as tissue depression, capillary dilation, skin atrophy, pigmentation and depigmentation were statistically compared between the two groups after treatment. Results:The total effective rate of the observation group was 93.3% (28/30), which was higher than that of the control group [73.3% (22/30), P=0.012]. After treatment, the scores of VSS, VAS and PSA in the observation group were lower than those in the control group (all P<0.05). The recurrence rate and adverse reaction rate of the observation group were 6.7% (2/30) and 6.7% (2/30), respectively, which were lower than that of the control group [43.3% (13/30) and 40.0% (12/30)], and the difference was statistically significant (all P<0.05). The adverse reactions in the observation group included tissue depression in 1 case and pigment loss in 1 case, while those in the control group included capillary dilation in 1 case, skin atrophy in 5 cases, pigmentation in 4 cases and pigment loss in 2 cases. Conclusion:The combination of CO 2 dot laser and BTX-A injection has a good effect on keloid and a low incidence of adverse reactions.
