Radiomics nomogram based on DBT for predicting expression level of Ki-67 in breast invasive ductal carcinoma
10.13929/j.issn.1003-3289.2025.03.017
- VernacularTitle:数字乳腺体层合成影像组学列线图预测乳腺浸润性导管癌Ki-67表达水平
- Author:
Mengyao GU
1
;
Qi CHEN
1
;
Li LIU
1
;
Jiajia QI
1
;
Wanhu LI
1
Author Information
1. 山东省肿瘤防治研究院(山东省肿瘤医院)山东第一医科大学(山东省医学科学院)影像科,山东济南 250117
- Publication Type:Journal Article
- Keywords:
breast neoplasms;
mammography;
radiomics;
Ki-67
- From:
Chinese Journal of Medical Imaging Technology
2025;41(3):429-433
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of digital breast tomosynthesis(DBT)-based radiomics nomogram for predicting Ki-67 expression levels in breast invasive ductal carcinoma(BIDC).Methods Data of 374 cases of BIDC were retrospectively analyzed and divided into high-expression group(n=224)and low-expression group(n=150)according to expression of Ki-67 as well as training set(n=271,162 cases in high-expression group and 109 cases in low-expression group)and test set(n=103,62 cases in high-expression group and 41 cases in low-expression group)at the ratio of 7∶3.Clinical characteristics and lesion's image manifestations were compared between groups,and radiomic features were extracted and filtered.Then imaging radiomics models were constructed with 8 classifiers,respectively,and the optimal classifier was selected.A nomogram model was subsequently developed through integrating image features and radiomics scores.Receiver operating characteristic curves were drawn,and the area under the curves(AUC)were calculated to evaluate the performance of the above models.Results Significant differences of the maximum diameter and spiculated margin of the lesions were found between groups(both P＜0.05),and AUC of multi-layer perceptron(MLP)image model constructed based on these indexes for predicting BIDC expression level of Ki-67 was 0.654 in training set and 0.715 in test set,of MLP radiomics model constructed based on 8 radiomics features was 0.802 in training set and 0.806 in test set,while of the nomogram model constructed based on image features and radiomics scores was 0.802 in training set and 0.806 in test set,respectively.Conclusion DBT-based radiomics nomogram could be used to effectively predict Ki-67 expression levels in BIDC.
