Pathophysiological mechanism of posterior reversible encephalopathy syndrome
10.13929/j.issn.1003-3289.2025.03.012
- VernacularTitle:可逆性后部脑病综合征病理生理学机制
- Author:
Xin JIN
1
;
Yan WANG
;
Siping LIU
;
Zhibing WANG
;
Zhiqiang ZHANG
Author Information
1. 扬州市中医院影像科,江苏扬州 225002
- Publication Type:Journal Article
- Keywords:
posterior leukoencephalopathy syndrome;
pathophysiology;
magnetic resonance imaging
- From:
Chinese Journal of Medical Imaging Technology
2025;41(3):404-408
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlations of spatial distribution frequency map of posterior reversible encephalopathy syndrome(PRES)and cerebral microvascular density map,cerebral blood flow(CBF)map,standard template of cerebral metabolic imaging and the spatial gene transcription map of human brain based on normative analysis strategy,and to analyze the pathophysiological mechanisms of PRES.Methods Cerebral MRI data of 184 patients with PRES were retrospectively analyzed.ROI of the lesions were delineated on T1WI,then registered to Montreal Neurological Institute(MNI)standard space.The spatial distribution frequency map of PRES lesions were obtained with superposition.Spatial correlation analysis were performed to observe correlations of spatial distribution frequency map of PRES and the cerebral microvascular density map,CBF map and standard template of cerebral metabolic imaging based on large sample.The potential related gene expressions were decoded based on gene expression data of Allen human brain atlas,and the correlations of spatial parts of PRES and those expressions were observed.Results No significant correlation was found between spatial distribution frequency map of PRES and cerebral microvascular density,CBF nor distribution of neurotransmitters(all P＞0.05).PLS1 weighted genes,VEGF-A gene,AQP-4 gene and RGS2 gene were all correlated with spatial distribution of PRES(r=-0.363-0.653,all P＜0.05),among which KCNAB3 gene had the highest weight(Z=17.288).Conclusion The spatial patterns of PRES risk or protective genes in brain regions were correlated with regional distribution of PRES lesions,which was consistent with arginine vasopressin(AVP)theory of the occurrence and development of PRES.
