Correlations of metabolite levels in medial prefrontal cortex and cancer-related depression in non-small cell lung cancer patients
10.13929/j.issn.1003-3289.2025.03.011
- VernacularTitle:非小细胞肺癌患者内侧前额叶皮质代谢物水平与肿瘤相关抑郁的相关性
- Author:
Jinhui LAN
1
;
Pengqiang LI
;
Huling REN
;
Yanfei WANG
;
Jing WANG
;
Yanli ZHANG
;
Yi ZHU
;
Yu DOU
Author Information
1. 兰州大学第一临床医学院,甘肃兰州 730000;兰州大学第一医院放射科,甘肃兰州 730000
- Publication Type:Journal Article
- Keywords:
lung neoplasms;
depressive disorder;
cerebral cortex;
magnetic resonance spectroscopy;
prospective studies
- From:
Chinese Journal of Medical Imaging Technology
2025;41(3):399-403
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the correlations of metabolite levels in medial prefrontal cortex(mPFC)and cancer-related depression(CRD)in patients with non-small cell lung cancer(NSCLC).Methods Totally 38 NSCLC patients were prospectively enrolled and divided into CRD group(n=23)and non CRD group(n=15)based on Hamilton depression scale(HAMD-17).Meanwhile,22 healthy individuals were taken as control group.1 H-MR spectroscopy was performed using Meshcher-Garwood point resolved spectroscopy sequence,then metabolite levels of mPFC were measured,and their correlations with HAMD-17 score were analyzed.Results Significant differences of gamma-aminobutyric acid(GABA)+/Water and glutamate/glutamine complex(Glx)/Water in mPFC were found among 3 groups.GABA+/Water in mPFC of CRD group was significantly lower than that of the other 2 groups(both P＜0.05),and Glx/Water in mPFC of CRD group was significantly lower than that of control group(P=0.034).In NSCLC patients,GABA+/Water in mPFC was negatively correlated with HAMD-17 score(r=-0.491,P=0.002).Conclusion GABA+/Water in mPFC was negatively correlated with HAMD-17 score in NSCLC patients.
