Efficacy and safety of fractional CO 2 laser combined with topical application of radix scutellariae ointment in treatment of hyperplastic scar
10.3760/cma.j.cn114657-20241113-00188
- VernacularTitle:点阵CO 2激光联合黄芩油膏外用治疗增生性瘢痕的疗效及安全性
- Author:
Qiuyue FU
1
;
Tianqi ZHANG
;
Wei CHEN
;
Shan ZHANG
;
Hao CHEN
;
Lina ZHOU
;
Gang CHEN
Author Information
1. 南京中医药大学附属医院（江苏省中医院）整形外科，南京 210029
- Publication Type:Journal Article
- Keywords:
Hyperplastic scar;
Fractional CO 2 laser;
Radix scutellariae ointment
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2025;31(2):126-130
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the clinical efficacy and safety of fractional CO 2 laser combined with topical application of radix scutellariae ointment in the treatment of hyperplastic scar. Methods:This randomized controlled trial prospectively enrolled 90 patients with hyperplastic scar treated with fractional CO 2 laser at the Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Province Hospital of Chinese Medicine) from January 2020 to December 2021. Participants were randomly divided into a trial group and a control group using a random number table. The trial group ( n=45, 22 males, 23 females, aged 18-54 years) received topical radix scutellariae ointment post-laser treatment, while the control group ( n=45, 23 males, 22 females, aged 19-55 years) received recombinant bovine basic fibroblast growth factor gel. Both groups underwent treatment every 3 months, with scar assessments conducted at 1-month post-treatment. Outcomes included Vancouver scar scale (VSS) scores, scar cosmesis assessment and rating (SCAR) scores, adverse reaction rates, and patients' satisfaction. Results:After the first, second, and third treatments, the trial group showed significantly lower VSS and SCAR scores compared to the control group (all P<0.05). Patients' satisfaction in the trial group was 91.1% (41/45), significantly higher than 77.8% (35/45) in the control group ( P=0.036). The adverse reaction rate in the trial group was 15.6% (7/45), and 28.9% (13/45) in the control group, there was no statistical difference ( P=0.813). Conclusion:Fractional CO 2 laser combined with topical radix scutellariae ointment demonstrate superior clinical efficacy, higher patient satisfaction, and lower adverse reaction rates in the treatment of hyperplastic scar.
