Expression of hsa_circ_0023984 in hepatic celluler cancer and construction of the ceRNA network
10.3969/j.issn.1673-9701.2025.08.002
- VernacularTitle:hsa_circ_0023984在原发性肝癌中的表达及ceRNA网络的构建
- Author:
Rusu QIN
1
;
Linghong WU
;
Shanxiong LIANG
;
Li YANG
;
Tianren HUANG
Author Information
1. 广西医科大学公共卫生学院,广西南宁 530021;广西医科大学附属肿瘤医院实验研究部,广西南宁 530021
- Publication Type:Journal Article
- Keywords:
Hepatic celluler cancer;
circRNA;
hsa_circ_0023984
- From:
China Modern Doctor
2025;63(8):5-8,20
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of hsa_circ_0023984 in hepatic celluler cancer(HCC)and its adjacent tissues and to analyze its clinical significance,and to construct an endogenous competitive RNA regulatory network.Methods CircRNA expression profiles of cancer tissue and adjacent tissue samples from GES97332 dataset in Gene Expession Omnibus database were downloaded and circRNA differential expression was screened.The expression of hsa_circ_0023984 was detected in the tissues of 34 HCC patients,and the relationship between it and the clinicopathological features was analyzed.The protein interaction network was constructed,and the function was further understood by gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis.Results The expression of hsa_circ_0023984 was lower in tumor tissues than in adjacent tissues.The expression level of hsa_circ_0023984 was related to the envelope condition(F=3.47,P＜0.05).Three targeted miRNAs were obtained,and the Hub genes were PARGC1,GNG 4,WNT 5 A,CDK 6,SP 1,KRAS,GNAI 3,NCOA3,PIK3R1,and MAPK 8.GO analysis and KEGG analysis indicated that downstream mRNAs of hsa_circ_0023984 may be involved in cancer pathways and the choline metabolism pathway in cancer.Conclusion High expression of hsa_circ_0023984 in primary HCC,and high expression of hsa_circ_0023984 may be related to the malignant development of primary HCC.
