Changes of serum MITOL,β-endorphin and CXCL10 in patients with herpes zoster virus infection and their predictive values
10.11816/cn.ni.2025-240927
- VernacularTitle:带状疱疹病毒感染血清MITOL、β-内啡肽和CXCL10水平变化及其预测价值
- Author:
Yanqin LAN
1
;
Jinglun XU
1
;
Fan XIE
1
;
Dongmei LIU
1
;
Hongying ZHOU
1
;
Han ZHANG
1
Author Information
1. 金华市第五医院皮肤科,浙江金华 321000
- Publication Type:Journal Article
- Keywords:
Herpes zoster;
Head and face;
Infection;
Mitochondrial ubiquitin ligase;
β-endorphin;
Chemokine 10
- From:
Chinese Journal of Nosocomiology
2025;35(6):858-861
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the changes of serum mitochondrial ubiquitin ligase(MITOL),β-endorphin(β-EP)and chemokine 10(CXCL10)in the patients with herpes zoster(HZ)virus infection and analyze the predic-tive values.METHODS A total of 137 patients with HZ virus infection who were treated in Jinhua Fifth Hospital from Jan.2022 to Jan.2024 were assigned as the infection group,meanwhile,100 healthy people who received physical examination were chosen as the healthy group.The clinical data were compared between the two groups,the levels of serum MITOL,β-EP and CXCL10 were detected for the two groups of participants.The changes of the above indexes were observed and compared.The values of serum MITOL,β-EP and CXCL10 in prediction of HZ virus infection were analyzed by means of receiver operating characteristic(ROC)curves.RESULTS There were significant differences in the levels of serum MITOL,β-EP and CXCL10 between the infection group and the healthy group(P＜0.05).As the serum MITOL,β-EP and CXCL10 were used for prediction of HZ virus infec-tion,the area under the curve(AUC)of the CXCL10 was the highest 0.932,with the sensitivity 91.24％,the specificity 81.00％;the AUC of the joint detection of the three indexes was 0.882,with the specificity 99.00％,the sensitivity 77.37％(P＜0.05).CONCLUSIONS The patients with HZ virus infection show the decline of MI-TOL and β-EP levels and the rise of CXCL10 level.The three indexes have high values in prediction of HZ virus infection,with the CXCL10 showing the best prediction efficiency.The indexes can be used for prediction of illness condition of the patients with HZ virus infection.
