Clinical Efficacy of Shenshuai Ⅱ Granules in the Treatment of Chronic Kidney Disease Stage 3-4 with Spleen-Kidney Qi Deficiency and Damp-Heat Stasis Syndrome and Its Effects on Free Fatty Acid
10.19879/j.cnki.1005-5304.202408330
- VernacularTitle:肾衰Ⅱ号颗粒治疗慢性肾脏病3～4期脾肾气虚、湿热瘀阻证患者临床疗效及对游离脂肪酸水平的影响
- Author:
Xiaolu DING
1
;
Zheng CAI
1
;
Chen WANG
1
Author Information
1. 上海中医药大学附属曙光医院,上海 201203
- Publication Type:Journal Article
- Keywords:
chronic kidney disease;
Shenshuai Ⅱ Granules;
lipid metabolism;
serum free fatty acids
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(4):152-156
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of Shenshuai Ⅱ Granules on patients with stage 3-4 chronic kidney disease(CKD)with spleen-kidney qi deficiency and damp-heat stasis syndrome and its effects on free fatty acid(FFA)levels.Methods A randomized double-blind clinical trial design was adopted,and 84 cases were included and randomly divided into a control group and a treatment group,with 42 cases in each group.The control group was given placebo granules,and the treatment group was given Shenshuai Ⅱ Granules,once a bag,twice a day,orally taken with warm water;the treatment for both groups lasted 3 months.Clinical efficacy and TCM syndrome efficacy of the two groups were evaluated.Renal function indicators(SCr,BUN,eGFR,24 hUP)and lipid metabolism indicators(FFA,TC,TG,LDL-C,HDL-C,LP(a),ApoA1 and ApoB)were detected and compared before and after treatment.The safety indicators of both groups were monitored.Results The total clinical effective rate of the treatment group was 83.33%(35/42),and the rate of the control group was 35.71%(13/42),with statistical significance(P<0.01);the therapeutic effect of TCM syndrome efficacy of the treatment group was 88.10%(37/42),and the rate of the control group was 40.48%(17/42),with statistical significance(P<0.01).Compared with before treatment,the levels of SCr,BUN,24-hour UP,FFA decreased in the treatment group,and eGFR increased(P<0.05,P<0.01).After treatment in the control group,SCr increased,while eGFR decreased(P<0.01).After treatment,the SCr,BUN and FFA levels in the treatment group were lower than those in the control group(P<0.01).There was no statistical significance in TC,TG,LDL-C,HDL-C,Lp(a),ApoA1 and ApoB between the two groups before and after treatment(P>0.05).No abnormal changes were observed in the safety indicators of the two groups of patients(P>0.05).Conclusion Shenshuai Ⅱ Granules integrated treatment with Western medicine can improve clinical symptoms and renal function-related indicators on patients with stage 3-4 CKD with spleen-kidney qi deficiency and damp-heat stasis syndrome,reduce serum FFA,and delay the progression of CKD.
