Distribution and drug resistance of pathogens and expressions of serum ESM-1,sTREM-1 and MIP-1α in acute respiratory distress syndrome patients with pulmonary infection
10.11816/cn.ni.2025-240479
- VernacularTitle:急性呼吸窘迫综合征肺部感染病原菌、耐药性及血清ESM-1、sTREM-1和MIP-1α表达
- Author:
Hu HAN
1
;
Litao ZHANG
1
;
Xin XU
1
Author Information
1. 河北省人民医院急诊医学科,河北石家庄 050051
- Publication Type:Journal Article
- Keywords:
Acute respiratory distress syndrome;
Pathogen;
Pulmonary infection;
Drug resistance;
Endothelial cell-specific molecule-1;
Macrophage inflammatory protein-1α;
Soluble triggering receptor expressed on myeloid cells-1
- From:
Chinese Journal of Nosocomiology
2025;35(5):647-651
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the distribution and pathogens isolated from the acute respiratory distress syn-drome(ARDS)patients with pulmonary infection and analyze the values of serum endothelial cell-specific mole-cule-1(ESM-1),soluble triggering receptor expressed on myeloid cells-1(sTREM-1)and macrophage inflamma-tory protein-1α(MIP-1α)in diagnosis of pulmonary infection.METHODS A total of 98 ARDS patients complicated with pulmonary infection who were treated in Hebei Provincial People's Hospital from Oct.2021 to Oct.2023 were assigned to the infection group,and 102 ARDS patients who were not complicated with pulmonary infection were chosen as the non-infection group.The distribution and drug resistance of the pathogens were analyzed.The levels of serum ESM-1,sTREM-1 and MIP-1α were compared between the two groups,and the values of the three inde-xes in diagnosis of pulmonary infection in the ARDS patients were analyzed.RESULTS Totally 112 strains of pathogens were isolated from the patients of the infection group,among which Klebsiella pneumoniae and Staph-ylococcus aureus were dominant.The drug resistance rates of K.pneumoniae strains to ceftriaxone and cefazolin were 56.52％and 52.17％,respectively;the drug resistance rates of the S.aureus strains to sulfamethoxazole-tri-methoprim,clindamycin and oxacillin were 75.00％,75.00％and 70.00％,respectively.The levels of serum ESM-1,sTREM-1 and MIP-1α of the infection group were higher than those of the non-infection group(P＜0.05);the area under the curve(AUC)value of the joint detection of the three indexes was higher than that of the single detection in diagnosis of the pulmonary infection in the ARDS patients(P＜0.05),and the sensitivity of the joint detection was 93.88％,with the specificity 84.31％.CONCLUSIONS K.pneumoniae and S.aureus are the predominant species of pathogens isolated from the ARDS patients complicated with pulmonary infection.The pa-tients show the high expressions of serum ESM-1,sTREM-1 and MIP-1α.The joint detection of the three indexes has high value in diagnosis of pulmonary infection in the ARDS patients.
