Efficacy of autologous platelet-rich plasma in the treatment of acute injury to the anterior talofibular ligament
10.3760/cma.j.cn115530-20250603-00238
- VernacularTitle:自体富血小板血浆治疗急性距腓前韧带损伤的疗效分析
- Author:
Liang LIU
1
;
Congcong ZENG
;
Yan XIAO
;
Zhenggang WANG
;
Lei XIANG
;
Hongbing JIANG
;
Cheng LIU
;
Shengyao LIU
;
Liangxing XIAO
;
Wei LIU
Author Information
1. 南华大学衡阳医学院附属南华医院创伤修复骨科，衡阳 421002
- Publication Type:Journal Article
- Keywords:
Platelet-rich plasma;
Ankle joint;
Ligaments;
Anterior talofibular ligament;
Lateral ankle ligament complex
- From:
Chinese Journal of Orthopaedic Trauma
2025;27(7):634-639
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical efficacy of autologous platelet-rich plasma (PRP) in the treatment of acute injury to the anterior talofibular ligament (ATFL).Methods:A retrospective study was conducted to analyze the data of 96 patients who had been admitted to Department of Orthopedic Trauma Repair, The Nanhua Hospital Affiliated to Hengyang Medical School for acute ATFL injuries of grades Ⅰ & Ⅱ from January 2022 to December 2023. They were divided into 2 groups according to their different treatments. In the PRP group subjected to local PRP injection combined with conservative treatment, there were 49 patients (28 males and 21 females), with an age of (32.5±6.5) years. In the conservative group subjected to traditional conservative treatment, there were 47 patients (24 males and 23 females), with an age of (30.5±5.3) years. The 2 groups were compared in terms of visual analog scale (VAS) pain scores, talar anterior translations, Karlsson scores, American Orthopaedic Foot & Ankle Society (AOFAS) ankle-hindfoot scores before and 6 months after treatment.Results:No statistically significant differences were observed in the baseline characteristics between the 2 groups before treatment, indicating comparability ( P>0.05). All patients were followed up for (9.1±1.7) months. In both groups, the VAS pain scores significantly decreased after treatment than the pre-treatment ones, the talar anterior translations significantly reduced after treatment than the pre-treatment ones, and the AOFAS and Karlsson scores significantly increased after treatment than the pre-treatment ones ( P < 0.05). After 6 months of treatment, the talar translation distance [(2.5±0.4) mm], AOFAS ankle hind foot score [(91.7 ± 4.0) points], and Karlsson score [(93.0±3.5) points] in the PRP group were significantly better than those in the conservative group [(6.1±0.9) mm, (87.1±4.3) points, (89.0±4.0) points]( P < 0.05). Conclusion:In the treatment of acute ATFL injury, PRP therapy demonstrates good clinical efficacy, for it can significantly reduce pain, promote functional recovery, and improve joint stability.
