Progress in the research into the role of mitophagy in peripheral nerve injury
10.3760/cma.j.cn115530-20250505-00190
- VernacularTitle:线粒体自噬在周围神经损伤中的作用研究进展
- Author:
Hui HAN
1
;
Sheng WANG
;
Aimin CHEN
Author Information
1. 同济大学附属上海市第四人民医院创伤骨科，上海 200434
- Publication Type:Journal Article
- Keywords:
Mitochondria;
Autophagy;
Peripheral nerves;
Regulatory mechanism;
Research progress
- From:
Chinese Journal of Orthopaedic Trauma
2025;27(8):732-736
- CountryChina
- Language:Chinese
-
Abstract:
Peripheral nerve injury is a serious nervous system disease. Due to its complex pathological mechanism and disordered nerve regeneration microenvironment, its clinical treatment still faces tough challenges. As a key mechanism for selective removal of damaged mitochondria, mitophagy plays an important regulatory role in the occurrence and development of peripheral nerve injury by maintaining the homeostasis of mitochondrial quality and quantity. In recent years, basic studies have revealed that moderate activation of mitophagy pathway can effectively alleviate peripheral nerve injury. This finding opens up a good prospect for the treatment of such diseases. This article reviews the regulatory mechanisms of mitophagy and their roles in different types of peripheral nerve injury, hoping to provide new ideas and theoretical basis for the clinical treatment of peripheral nerve injury.
