Advance on pathogenesis,diagnosis and treatment of acute gastrointestinal injury in critically ill patients
10.3969/j.issn.1008-9691.2025.01.022
- VernacularTitle:危重症患者急性胃肠功能损伤的发病机制及诊治研究进展
- Author:
Wenqian HUO
1
;
Gaiqi YAO
1
Author Information
1. 北京大学第三医院危重医学科,北京 100091
- Publication Type:Journal Article
- Keywords:
Acute gastrointestinal injury;
Intensive care unit;
Intestinal mucosal barrier;
Review
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2025;32(1):110-114
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,gastrointestinal dysfunction in critically ill patients has attracted increasing attention from clinicians.However,due to the heterogeneity of clinical manifestations and the variability in objective evaluation indicators,standardized diagnostic and assessment criteria remain lacking.In 2012,the European Society of Intensive Care Medicine(ESICM)introduced the concept of acute gastrointestinal injury(AGI),defining it as gastrointestinal dysfunction resulting from acute illness in critically ill patients.The pathophysiological mechanisms of AGI are complex,involving inflammatory responses,gastrointestinal mucosal barrier integrity,and gut microbiota dysbiosis.The onset of AGI is often insidious,and a precise system for the identification and evaluation of gastrointestinal dysfunction is still absent.This review summarizes the definition and grading of AGI,its pathophysiological mechanisms,clinical diagnosis and assessment methods,and therapeutic strategies,aiming to elucidate recent advances in understanding gastrointestinal dysfunction in critically ill patients and to provide guidance for the early identification of AGI.
